Photo: Todd Kirkland / Getty Images Sport / Getty Images
According to our computer model, the Carolina Panthers will take down the Buffalo Bills when the two teams play at Bank of America Stadium on Sunday, Oct. 26, which kicks off at 1 p.m. ET. For our projections on the spead, point total, and final score, see the rest of the article below.
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Bills vs. Panthers Game Info and TV Channel
- When: Sunday, October 26, 2025 at 1 p.m. ET
- Where: Bank of America Stadium in Charlotte, North Carolina
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 99.7 The Fox
Bills vs. Panthers Odds and Betting Info
- Spread favorite: Bills (-7.5)
- Moneyline: Bills (-400), Panthers (+313)
- Total: 46.5 points
Bills vs. Panthers Prediction
- Pick ATS: Panthers (+7.5)
- Pick OU: Over (46.5)
Prediction:
Panthers 24 - Bills 22
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Bills vs. Panthers Betting Insights
- The Bills have covered twice in six matchups with a spread this season.
- The Panthers are 5-2-0 ATS this year.
- Buffalo has been favored by 7.5 points or more this season three times and failed to cover in all three.
- A total of three out of six Bills games this season have hit the over.
- The Panthers and their opponent have combined to hit the over four out of seven times this season.
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