Sabres vs. Red Wings Prediction & Picks - Oct. 22

Toronto Maple Leafs v Detroit Red Wings

Photo: Nic Antaya / Getty Images Sport / Getty Images

The Buffalo Sabres (2-4) square off against the Detroit Red Wings (5-1) at KeyBank Center on Wednesday, Oct. 22 at 7:30 p.m. ET on TNT. The Sabres fell to the Montreal Canadiens 4-2 in their most recent outing, while the Red Wings are coming off a 4-2 win over the Edmonton Oilers.

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Before watching this matchup, here's a look at which squad we think will bring home the victory in Wednesday's action on the ice.

Sabres vs. Red Wings Predictions for Wednesday

Our computer model for this matchup predicts a final tally of Red Wings 4, Sabres 3.

  • Moneyline Pick: Red Wings (-105)
  • Total Pick: Under 6 (computer predicts 5.6 goals on average)
  • Spread Pick: Red Wings (+1.5)

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Sabres Splits and Trends

  • In the two games this season the Sabres recorded only one goal, they lost both times.
  • Buffalo has lost the only game this season when it scored exactly two goals.
  • The Sabres have scored more than two goals two times, and are 2-0-0 in those games.
  • When it has outshot its opponent, Buffalo is winless (0-2-0).
  • The Sabres have been outshot by opponents four times, and went 2-2-0 (four points).

Red Wings Splits and Trends

  • The Red Wings have posted a record of 1-0-1 in overtime games to contribute to an overall mark of 5-1.
  • Detroit has won both of its games that were decided by one goal.
  • This season the Red Wings registered just one goal in one game and they lost that matchup.
  • Detroit has won the only game this season when it scored two goals (1-0-0, two points).
  • So far this season, the Red Wings have scored at least three goals four times and won each of those games.
  • Detroit has scored a lone power-play goal in four games this season and has recorded six points from those matchups.
  • When outshooting its opponent this season, Detroit is 3-1-0 (six points).
  • The Red Wings have been outshot by opponents twice, and won both times.

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Team Stats Comparison

Sabres Rank Sabres AVG Red Wings AVG Red Wings Rank
28th 2.5 Goals Scored 3.33 8th
17th 3 Goals Allowed 2.33 7th
8th 29.7 Shots 26.8 18th
31st 33.3 Shots Allowed 25.2 6th
6th 26.32% Power Play % 22.22% 15th
2nd 95.83% Penalty Kill % 92.31% 4th

Sabres vs. Red Wings Game Time and TV Channel

  • When: Wednesday, October 22, 2025 at 7:30 p.m. ET
  • TV Channel: TNT
  • Live Stream: Watch this match on HBO Max (Regional restrictions may apply)
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)
  • Where: KeyBank Center in Buffalo, New York

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