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The Pittsburgh Panthers (4-2) take on a conference opponent when they visit the Syracuse Orange (3-3) on Saturday, October 18, 2025 at the JMA Wireless Dome in an ACC battle.
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Pittsburgh vs. Syracuse Matchup Info
- Game date: Saturday, October 18, 2025
- Game time: 7:30 p.m. ET
- Location: Syracuse, New York
- Venue: JMA Wireless Dome
- TV channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Pittsburgh vs. Syracuse Odds and Prediction
- Spread favorite: Panthers (-9.5)
- Moneyline: Panthers (-365), Orange (+286)
- Total: 54.5 points
- Pick ATS: Pittsburgh (-9.5)
- Pick OU: Over (54.5)
- Prediction: Pittsburgh 34, Syracuse 22
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Pittsburgh vs. Syracuse Betting Records and Insights
- Pittsburgh has compiled a 4-2-0 record against the spread this season.
- Syracuse is 3-2-1 ATS this season.
- The Panthers have covered the spread when playing as at least 9.5-point favorites in two of two chances this season.
- The Orange have covered the spread twice when an underdog by 9.5 points or more this season (in three opportunities).
- A total of four out of six Pittsburgh games this season have hit the over.
- Syracuse games have gone over the point total three out of six times this season.