When the Buffalo Bills play the New England Patriots at 8:20 p.m. ET on Sunday, Oct. 5, our computer model predicts the Bills will come out on top. Our model also projects the spead, point total, and final score, which you can see below.
Don't miss a touchdown this NFL season. Catch every score with NFL RedZone on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and watch seven hours of football from every NFL game every Sunday.
Bills vs. Patriots Game Info and TV Channel
- When: Sunday, October 5, 2025 at 8:20 p.m. ET
- Where: Highmark Stadium in Orchard Park, New York
- TV: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Catch every NFL touchdown with NFL RedZone on Fubo.
Listen to the game on WGR 550 SportsRadio
Bills vs. Patriots Odds and Betting Info
- Spread favorite: Bills (-7.5)
- Moneyline: Bills (-437), Patriots (+340)
- Total: 49.5 points
Bills vs. Patriots Prediction
- Pick ATS: Patriots (+7.5)
- Pick OU: Over (49.5)
Prediction:
Bills 29 - Patriots 22
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
See how these predictions pan out and sign up for NFL RedZone on Fubo to catch every score on Sundays this fall.
Bills vs. Patriots Betting Insights
- The Bills have covered twice in four games with a spread this season.
- The Patriots have a record of 2-2-0 against the spread this year.
- Buffalo has not covered the spread this season (0-2 ATS) when playing as at least 7.5-point favorites.
- So far this season, three out of the Bills' four games have gone over the point total.
- This season, games featuring the Patriots have gone over the point total twice.
Looking for NFL tickets? Head to StubHub today and see your team live.