In the game between the Buffalo Bills and New Orleans Saints on Sunday, Sept. 28 at 1 p.m. ET, our computer model expects the Bills to come away with the victory. Seeking projections on the final score, spread, and point total, too? Find a full game projection below.
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Bills vs. Saints Game Info and TV Channel
- When: Sunday, September 28, 2025 at 1 p.m. ET
- Where: Highmark Stadium in Orchard Park, New York
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Listen to the game on WGR 550 SportsRadio
Bills vs. Saints Odds and Betting Info
- Spread favorite: Bills (-14.5)
- Moneyline: Bills (-1429), Saints (+818)
- Total: 48.5 points
Bills vs. Saints Prediction
- Pick ATS: Bills (-14.5)
- Pick OU: Under (48.5)
Prediction:
Bills 34 - Saints 14
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Bills vs. Saints Betting Insights
- The Bills have covered twice in three games with a spread this season.
- The Saints have put together a 0-3-0 record against the spread this year.
- This season, games featuring the Bills have hit the over twice.
- This season, games featuring the Saints have hit the over twice.
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