ACC opponents meet when the Duke Blue Devils (2-2) and the Syracuse Orange (3-1) play on Saturday, September 27, 2025 at the JMA Wireless Dome.
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Duke vs. Syracuse Matchup Info
- Game date: Saturday, September 27, 2025
- Game time: 12 p.m. ET
- Location: Syracuse, New York
- Venue: JMA Wireless Dome
- TV channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Duke vs. Syracuse Odds and Prediction
- Spread favorite: Blue Devils (-4.5)
- Moneyline: Blue Devils (-190), Orange (+156)
- Total: 59.5 points
- Pick ATS: Duke (-4.5)
- Pick OU: Over (59.5)
- Prediction: Duke 35, Syracuse 28
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Duke vs. Syracuse Betting Records and Insights
- Duke has a record of 1-3-0 against the spread this season.
- Syracuse has a record of 2-1-1 against the spread this season.
- The Blue Devils have been favored by 4.5 points or more this season once, and failed to cover the spread.
- The Orange have been an underdog by 4.5 points or more two times this season, and covered the spread in one of those games.
- So far this season, each Duke game has hit the over.
- Syracuse games have hit the over three out of four times this season.