James Cook Week 13 Preview vs. the 49ers

Buffalo Bills running back James Cook will face a middle-of-the-pack run defense in Week 13 (Sunday at 8:20 PM ET), up against the San Francisco 49ers. The 49ers are ranked 11th in terms of rushing yards conceded, at 110.8 per game.

So far this season, Cook has compiled a team-best 596 rushing yards on 137 carries (59.6 ypg), while scoring 10 rushing TDs. Cook has collected 25 catches this season for 182 yards and one touchdown.

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Cook vs. the 49ers

• Cook vs the 49ers (since 2021): No games
• The 49ers have allowed 100 or more yards on the ground to one opposing rusher during the 2024 season.
• San Francisco has given up one or more rushing TDs to 12 opposing players this year.
• Three opposing rushers have scored two or more TDs on the ground against the 49ers this season.
• The 110.8 rushing yards per game given up by the 49ers defense makes them the NFL's 11th-ranked run defense.
• Opponents of the 49ers have totaled 16 touchdowns on the ground (1.5 per game). The 49ers' defense is 28th in the NFL in that category.

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Cook Rushing Insights

• Cook has hit the rushing yards over in five of 10 opportunities (50.0%).
• The Bills pass on 52.7% of their plays and run on 47.3%. They are fifth in NFL play in points scored.
• He has carried the ball in 137 of his team's 307 total rushing attempts this season (44.6%).
• In seven games this year, Cook has run for at least one touchdown, including three games with multiple rushing TDs.
• He has 30.6% of his team's 36 offensive touchdowns this season (11).
• He has 31 red zone carries for 43.1% of the team share (his team runs on 62.1% of its plays in the red zone).

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Cook's Recent Performance