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The Buffalo Bills are expected to come out on top in their matchup against the New England Patriots at 1 p.m. ET on Sunday, Oct. 4, based on our computer projection model. If you're wanting more predictions on the final score, spread, and point total, we list those numbers below.
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Patriots vs. Bills Game Info and TV Channel
- When: Sunday, October 4, 2026 at 1 p.m. ET
- Where: New Highmark Stadium in Orchard Park, New York
- TV: CBS
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Listen to the game on WGR 550 SportsRadio
Patriots vs. Bills Odds and Betting Info
- Spread favorite: Bills (-6.5)
- Moneyline: Bills (-332), Patriots (+266)
- Total: 49.5 points
Patriots vs. Bills Prediction
- Pick ATS: Patriots (+6.5)
- Pick OU: Under (49.5)
Prediction:
Bills 23 - Patriots 21
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Patriots vs. Bills Betting Insights
- The Bills have compiled a perfect 3-0-0 record against the spread this season.
- The Patriots have a record of 1-1-1 against the spread this season.
- Buffalo has covered the spread when playing as at least 6.5-point favorites in their only opportunity this season.
- So far this season, two Bills games have hit the over.
- So far this season, no Patriots games have hit the over.
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